Comfortis spinosad


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What is Comfortis (spinosad)?
Comfortis is the first FDA-approved, chewable beef-flavored tablet (derived from pork protein and hydrolyzed soy) that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

Dogs & Cats (14 weeks of age or older)

Starts killing fleas within 30 minutes
Lasts a full month
Kills fleas before they can lay eggs
Comes in a convenient chewable, beef-flavored tablet
Spinosad, the active ingredient in Comfortis, is environmentally friendly
Comfortis is the #1 recommended Rx Flea-only medication for dogs and cats

How does Comfortis work?
The active ingredient in Comfortis (Spinosad) kills fleas by causing excitation of the insect’s nervous system, leading to paralysis and rapid death.

Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Ivermectin is an ingredient found in heartworm preventatives such as Heartgard Plus, Heartgard, Iverhart Plus and Ivomec. In cats, the most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. For complete safety information, see product label.

Brand Name:
Comfortis (Elanco)

Generic Name:

What is the most important information I should know about Comfortis?
Comfortis is a prescription medication FDA approved for use in dogs and puppies and cats and kittens 14 weeks of age or older to kill fleas and prevent flea infestations for one month. Comfortis is available in a Pink box for dogs 5 to 10 lbs and cats 4.1-6 lbs (140 mg), Orange box for dogs 10.1 to 20 lbs and cats 6.1-12 lbs (270 mg), Green box for dogs 20.1 to 40 lbs and cats 12.1-24 (560 mg), Blue box for dogs 40.1 to 60 lbs (810 mg), and Brown box for dogs 60.1 to 120 lbs (1620 mg). Please note: Cats over 24 lbs should be administered the appropriate combination of tablets.

What should I discuss with my veterinarian before giving Comfortis to my pet?
Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog or cat has a history of seizures (epilepsy).

How should Comfortis be given?
Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77 F)

Comfortis is an easy-to-give oral treatment that doesn’t make a mess

What are the potential side effects of Comfortis?
Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, incoordination, weight loss, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, incoordination, excessive dilation of pupils, blindness and disorientation. Post-approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions.Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What happens if I miss giving a dose of Comfortis?
Give the missed dose as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose my pet on Comfortis?
Contact your veterinarian immediately.

What should I avoid while giving Comfortis?
Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated.

What other drugs will affect Comfortis?
Talk to your veterinarian before giving any prescription or over the counter medications.

Comfortis is trusted by vets and has been prescribed over 90 million times

Additional information


6 dose


140 mg spinosad, 270 mg spinosad, 560 mg spinosad, 810 mg spinosad, 1620 mg spinosad


Pink, Orange, Green, Blue, Brown


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